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MarScreen® |
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Sperm Antibody Serum Controls |
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ImmunoSpheres® |
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Hi/Lo QC Beads |
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AcroScreen™ |
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CitricScreen® |
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FructoScreen® |
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LeucoScreen™ |
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ImmunoSpheres®
Bead Method for the Detection of Sperm-Reactive IgA, IgG, IgM and Ig (Heavy
and Light Chains) Antibodies
- 140 determinations per reagent
- similar to the ImmunoBeadsTM Test(IBT)
- improvement over IBT-- see comparison below
There is considerable evidence that antibodies directed against sperm surface antigens
exert a fertility-reducing effect. When antisperm antibodies are present, they bind to the
surface of the sperm. Such sperm-bound antibodies may impair sperm movement,
penetration of the cumulus and/or zona pellucida, the acrosome reaction, interaction of
sperm and egg as well as identify the sperm for destruction by the immune system. It
has also been suggested that sperm antibodies may exert an embryotoxic effect.
Finally, there is evidence that antibody concentration is correlated directly with the severity
of sperm functional impairment and inversely with potential fertilizability.
For these reasons, many reproductive specialists screen sperm and/or serum for anti-sperm antibodies
before choosing an appropriate Assisted Reproductive Technology.
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ImmunoSpheres and ImmunoBeads mixed on
a slide, 400X. Courtesy of Grace M. Centola.
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| Beads
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monodispersed
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tend to
clump
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| Bead Size
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uniform 3.0um
latex
beads
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non-uniform size
beads can be
mistaken
for cellular debris
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| Bead
Color
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blue
for Anti-IgG
red for Anti-IgA
green
for Anti-IgM
white for Anti-Ig(H&L)
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translucent
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| Bead
Preparation
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wash each
time
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weigh out and
wash each
time
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| Microscopy
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bright field or phase
contrast
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phase
contrast
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| Shelf
Life
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18 months
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1 month
once reconstituted
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BS-SPHERES-A |
ImmunoSpheres IgA
Bead Method for the Detection of Sperm-Reactive Antibodies |
1 each (140 det.) |
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BS-SPHERES-G |
ImmunoSpheres IgG
Bead Method for the Detection of Sperm-Reactive Antibodies |
1 each (140 det.) |
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BS-SPHERES-M |
ImmunoSpheres IgM
Bead Method for the Detection of Sperm-Reactive Antibodies |
1 each (140 det.) |
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BS-SPHERES-IG |
ImmunoSpheres Ig (H&L)
Bead Method for the Detection of Sperm-Reactive Antibodies |
1 each (140 det.) |
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 Product Information
| ImmunoSpheres IgA - Bead Method for the Detection of Sperm-Reactive Antibodies
| | ImmunoSpheres IgG - Bead Method for the Detection of Sperm-Reactive Antibodies
| | ImmunoSpheres IgM - Bead Method for the Detection of Sperm-Reactive Antibodies
| | ImmunoSpheres Ig (H&L) - Bead Method for the Detection of Sperm-Reactive Antibodies
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MSDS
| ImmunoSpheres IgA - Bead Method for the Detection of Sperm-Reactive Antibodies
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MSDS
| ImmunoSpheres IgG - Bead Method for the Detection of Sperm-Reactive Antibodies
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MSDS
| ImmunoSpheres IgM - Bead Method for the Detection of Sperm-Reactive Antibodies
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MSDS
| ImmunoSpheres Ig (H&L) - Bead Method for the Detection of Sperm-Reactive Antibodies
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Package Insert
| ImmunoSpheres IgA - Bead Method for the Detection of Sperm-Reactive Antibodies
| | ImmunoSpheres IgG - Bead Method for the Detection of Sperm-Reactive Antibodies
| | ImmunoSpheres IgM - Bead Method for the Detection of Sperm-Reactive Antibodies
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Package Insert
| ImmunoSpheres Ig (H&L) - Bead Method for the Detection of Sperm-Reactive Antibodies
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