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Sperm Antibody and Sperm Function Assays
MarScreen®
Sperm Antibody Serum Controls
ImmunoSpheres®
Hi/Lo QC Beads
AcroScreen™
CitricScreen®
FructoScreen®
LeucoScreen™


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MarScreen®




Description

Bead Method for the Detection of Sperm-Reactive IgA, IgG and IgM Antibodies


Features
  • 140 determinations per reagent
  • 2 Component Kit
  • direct method performed on fresh unprocessed semen
  • can be performed and analyzed in less than 10 minutes
  • uniform colored beads for easy-to-read results
  • only reagents available that detect IgA, IgG and IgM antibodies using the Mixed Agglutination Reaction
  • improvement over SpermMar™
  • Competitively priced
  • built-in positive control

Background

There is considerable evidence that antibodies directed against sperm surface antigens exert a fertility-reducing effect. When antisperm antibodies are present, they bind to the surface of the sperm. Such sperm-bound antibodies may impair sperm movement, penetration of the cumulus and/or zona pellucida, the acrosome reaction, interaction of sperm and egg as well as identify the sperm for destruction by the immune system. It has also been suggested that sperm antibodies may exert a embryotoxic effect. Finally, there is evidence that antibody concentration is correlated directly with the severity of sperm functional impairment and inversely with potential fertilizability.

Because of the risks associated with intracytoplasmic Sperm Injection (ICSI), many reproductive specialists screen sperm for anti-sperm antibodies before choosing the appropriate Assisted Reproductive Technology.


Comparison

  MarScreen® SpermMar™
Colored Beads
Colored beads make observation of isotype-specific agglutination easier  
Yes
IgG/Blue, IgA/Red, IgM/Green
No
Latex Bead Size
Larger bead size provides better visibility for a clearer interpretation  
3.0µm 2.4 µm
# of Determinations
70 50
External Control
+/- Controls for Anti-IgG  
Yes Yes
Internal Control Yes Yes



Ordering Information

product # product name order multiple
BS-MAR-A MarScreen IgA
A Bead Method for the Detection of Sperm-Reactive IgA Antibodies
1 each ( 70 det.)
BS-MAR-G MarScreen IgG
A Bead Method for the Detection of Sperm-Reactive IgG Antibodies
1 each ( 70 det.)
BS-MAR-M MarScreen IgM
A Bead Method for the Detection of Sperm-Reactive IgM Antibodies
1 each ( 70 det.)


Literature

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PDFProduct Information
MarScreen IgA - A Bead Method for the Detection of Sperm-Reactive IgA Antibodies
MarScreen IgG - A Bead Method for the Detection of Sperm-Reactive IgG Antibodies
MarScreen IgM - A Bead Method for the Detection of Sperm-Reactive IgM Antibodies

PDFMSDS
MarScreen IgA - A Bead Method for the Detection of Sperm-Reactive IgA Antibodies

PDFMSDS
MarScreen IgG - A Bead Method for the Detection of Sperm-Reactive IgG Antibodies

PDFMSDS
MarScreen IgM - A Bead Method for the Detection of Sperm-Reactive IgM Antibodies

PDFPackage Insert
MarScreen IgA - A Bead Method for the Detection of Sperm-Reactive IgA Antibodies

PDFPackage Insert
MarScreen IgG - A Bead Method for the Detection of Sperm-Reactive IgG Antibodies

PDFPackage Insert
MarScreen IgM - A Bead Method for the Detection of Sperm-Reactive IgM Antibodies


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